The multi-zone network model method, together with the wind tunnel test and CFD numerical simulation results, was employed to simulate the combined wind and stack effects of a high rise building with the height of 340 m. It was concluded that: 1）The differential pressure curves between the indoor elevator and outdoor were linear under pure stack effect, which were consist with the theoretical result. The differential pressure between the indoor elevator and outdoor was gradually dominated by the wind effect with the increase of wind speed, and its curve gradually changed from linear distribution to nonlinear distribution. Higher wind speed would lead to significant nonlinear feature. 2）The neutral plane level of the building was hardly affected by the outdoor wind speed，and the refuge floors had great influences on the differential pressure elevators on the refuge floor and its neighboring floors; 3) Different wind on different seasons would have different impacts on the stack pressures. For one high frequency ENE wind in winter, the wind pressure would depress the stack pressure generally，while for another N wind，the wind pressure would strengthen the stack pressure by contrast. Under the ESE wind in summer，the wind pressure would depress the stack pressure on the floors except for the refuge floor，while an opposite effect would occur on the refuge. 4） Measures such as improving the sealing level of the glass curtain and/or adding additional partitions were helpful to mitigate the excessive differential pressure caused by stack effect.