Three kinds of 2219 aluminum alloy with different Fe contents have been produced by ultrasonic semi-continuous cast. The influence of Fe content on microstructure and properties of 2219 aluminum alloy was investigated by OM, SEM, tensile tests and electrochemical corrosion experiment. The results showed that the mechanical properties and corrosion resistance decrease obviously with the increase of Fe content, which attribute to the generation of massive primary Al7Cu2(FeMn) phase and the increase of volume fraction of residual crystal phase. The tensile fracture behavior of 2219 aluminum alloy at room temperature was mainly influenced by the brittle fracture of Al7Cu2(FeMn) phase, the crack direction of Al2Cu phase formed in the forging process and the low bonding strength at coarse residual crystal phase/ Al matrix interfaces.