厘清骨骼不同解剖学区域的力学性能差异可为构建高生物逼真度的骨骼有限元 模型提供重要依据. 从牛股骨中段的前、后、内、外四个解剖学区域各制备一个试样，采用玻式 压头对每个试样分别进行18个点的纳米压痕试验，记录加载力和压入深度的时间历程曲线， 获得各压痕点的压入模量和硬度 . 结果显示长骨前侧、后侧、外侧、内侧的压入模量分别为 20.78 ± 2.66 GPa、18.66 ± 2.57 GPa、16.39 ± 2.29 GPa、21.57 ± 2.19 GPa，硬度分别为0.65 ± 0.79 GPa、0.58± 0.08 GPa、0.44 ± 0.06 GPa、0.61 ± 0.15 GPa. 方差分析表明，解剖学区域对压入模量 和硬度的影响显著（p < 0.001）；组间多重比较表明，前侧试样的压入模量和硬度显著高于外侧 试样，内侧试样的压入模量和硬度显著高于外侧试样，后侧试样的硬度显著高于外侧试样，内 侧试样的压入模量显著高于外侧试样 . 因此，采用非均一材料将有助于提升长骨有限元模型 的生物逼真度.
Clarifying the differences of mechanical properties in different anatomical regions of bone can provide an important basis for constructing the finite element model of the bone with high biofidelity. One sample was pre? pared from each of the anterior，posterior，medial，and lateral anatomical regions of the bovine femoral shaft. Each sample was tested at 18 points utilizing a Berkovich nanoindenter tip，and the time history of the loading force and in? dentation depth was recorded to obtain the indentation modulus and hardness. The indentation modulus of the ante? rior，posterior，medial and lateral regions of the long bone were 20.78 ± 2.66 GPa，18.66 ± 2.57 GPa，16.39 ± 2.29 GPa，21.57 ± 2.19 GPa respectively，and hardness were 0.65 ± 0.79 GPa，0.58 ± 0.08 GPa，0.44 ± 0.06 GPa，0.61 ± 0.15 GPa respectively. Variance analysis showed that anatomical region had a significant effect on indentation modulus and hardness（p < 0.001）. Multiple comparisons between groups showed that the indentation modulus and hardness of the anterior specimen were significantly higher than those of the lateral specimen，the indentation modu? lus and hardness of the medial specimen were significantly higher than those of the lateral specimen，the hardness of the posterior specimen was significantly higher than that of the lateral specimen，and the indentation modulus of the medial specimen was significantly higher than that of the lateral specimen. Therefore，the use of heterogeneous mate? rials can help to improve the biological fidelity of the finite element model of the long bone.
张冠军 ?,顾红跃 ,陈萍 ,李振涛 ,贾晓航.基于纳米压痕测试的骨骼力学 特性解剖学区域差异研究[J].湖南大学学报：自然科学版,2022,(2):47~54复制