A terahertz fundamental up-conversion mixer with a high local oscillator (LO)/ radio frequency (RF) and local oscillator / intermediate frequency (IF) port isolation was presented, which was in the IHP 0.13μm SiGe BiCMOS process. The mixer adopted Gilbert’s double-balanced structure, local oscillator signal was transmitted through the Coplanar Waveguide (CPW) to suppress the transmission asymmetry caused by the strong parasitic coupling effect in the transmission process, which reduced the characteristic of LO/RF port isolation deterioration caused by the asymmetry. By adopting an asymmetric switch interconnection structure, the imbalance of the parasitic coupling of the local oscillator signal at the collectors of the switching transistors was reduced, and the cancellation efficiency of the local oscillator signal at the collectors of the switching transistors was improved. And the local oscillator signal was suppressed at the port of intermediate frequency by arranging the position of the transconductance transistors in a reasonable layout. The post-simulation results show that under the power supply voltage of 2.2V, the local oscillator signal is 230GHz and the intermediate frequency signal is 2-12GHz, when the up-conversion mixer works at 218-228GHz, the LO/RF port isolation is greater than 24dB, LO/IF port isolation is greater than 20dB, the conversion gain is -4dB to-3.4dB. The output 1dB compression point is -14.8dBm with an intermediate frequency signal is 10GHz. The DC power consumption is 42.4mW, the core area of the chip is 0.079mm2.