Vehicle traveling can cause bridge vibration. As the span increases， bridge non-linearity increases and vehicle-bridge interaction becomes more pronounced. In this paper， a 575m long-span concrete-filled steel tubular arch bridge， Guangxi Pingnan Third Bridge， is taken as the study objective. Pulsation tests and accessibility field tests were carried out on it. Meanwhile， a refined vehicle-bridge coupling finite element model was established. Vehicle-bridge coupling vibration response under different vehicle speeds and vehicle weights was analyzed to explore its response law. Besides， the dynamic coefficient of control sections of the bridge is also calculated and compared with that calculated by the current code to discuss the applicability of the current code to this bridge. The results show that the numerical results are in good agreement with the results of the field pulsation tests， and the trend of the dynamic strain time course curve under different conditions is basically the same as that of the field tests. There is no significant relationship between the dynamic response of the bridge and the vehicle speed within the speed range of 20 km/h to 60 km/h. When the vehicle exceeds 60 km/h， the deflection increases sharply with the speed. The increase in vehicle weight leads to an increase in the maximum dynamic deflection of the bridge and a decrease in the impact coefficient， but the actual total response of the bridge does not decrease. Therefore， the speed and weight of the vehicles crossing the bridge should be strictly controlled to effectively reduce the impact effect of the traffic load on the bridge.