The Finite Element Method (FEM) model of Wuhan Junshan Yangtze River Bridge was established, and the dynamic characteristics, nonlinear seismic responses under uniform and non-uniform excitations, and the seismic control measures were systematically studied. The results show that: 1) the basic cycle of Wuhan Junshan Yangtze River Bridge is about 8.881s, which is very long. Its first mode of vibration is longitudinal floating mode. 2) The geometric nonlinearity has much influence on the response of this kind of bridge. 3) The non-uniform excitations are unfavorable to the design of tower and the main girder when considering the three orthogonal seismic wave input. 4）The replacement of normal bearing by the LRB or VED or LRB+VED is favorable to the seismic control, but it is prior to adopt the type of LRB+VED.