This experiment was carried out by Trichoderma reesei HC -415 according to Shake -flask orthogonal tests 1 and 2 and Shake -flask fermentation medium -2 test, which determined the consumption level of straw and bean cake powder in 30 L fermenter. We tracked the variation of pH and DO of fermentation liquor and the activity of cellulase changing over time, studied the extraction of cellulase, and calculated the yield. The average enzymic activity of the lyophilized cellulase of CMC was 355.0 IU/g, and 44.3 IU/g for FPA.The relative yield of fermentation liquor was 16.00 g/L.The enzymic activity yield of fermentation liquor for CMC was 77.16%,and 58.10% for FPA.