Synthesis of Quinolone-bonded Porphyrins and Their Interaction with Bovine Serum Albumin
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摘要:
基于卟啉化合物的光敏性和对肿瘤细胞有特殊的亲和力以及喹诺酮类化合物的抗癌活性,设计合成了10个喹诺酮键联卟啉化合物,其结构由1H NMR, IR, UV-Vis和MS表征.同时,利用荧光光谱考察了上述喹诺酮键联卟啉与牛血清白蛋白(BSA)的相互作用,结果表明它们对BSA荧光有较强的静态猝灭作用.
Abstract:
Ten quinolone-bonded porphyrins were designed and synthesized on the basis of both porphyrin’s photosensitivity and special affinity for tumor cells and quinolones’ antitumor and anticancer activities. The molecular structures of all synthesized compounds were characterized with 1H NMR, IR, UV-Vis and MS. The interaction between quinolone-bonded porphyrins and bovine serum albumin (BSA) was investigated with fluorescence spectrum. The results have shown that these new quinolone-bonded porphyrins have a powerful ability of quenching the fluorescence of BSA via static quenching.