In this paper, sum flow rate-damper signal and highest load ratio-minimum flow rate were presented to optimize the supply air static pressure and the temperature of Variable Air Volume (VAV) system. This scheme was applied to the VAV system of a building. The models of VAV system were established, and TRNSYS was used to stimulate the duct system of the typical floor. The models were certified with measurement data. The energy consumption of VAV fan before and after the optimization was stimulated on typical days. The stimulation results show that, compared with constant static pressure and constant air temperature control scheme, the original one, the optimal scheme can save the energy consumption of Air Handling Unit (AHU) fan, especially in part load situation. The energy saving ratio reaches 19.38% and 15.58% on the test days of winter and transition season, respectively. Experiments were conducted to compare the whole year energy consumption and the indoor thermal comfort with two schemes. The results show that the whole year energy saving ratio reaches 7.16%. Indoor thermal comfort is improved remarkably.