The wind-resistant performance of Jiang-shun Bridge in Guangdong, a cable-stayed bridge with a main span of 700 meters, was investigated by means of wind tunnel tests and computational fluid dynamics method (CFD). The experiments and numerical simulations of the aerodynamic parameters of the main deck and pylon, the wind-induced vibration experiments of the main deck with a sectional model with a geometry scale of 1 to 60, the vortex-induced vibrations (VIV) experiments of the main deck with sectional model with geometry scale of 1 to 25, and the wind tunnel tests of the full bridge aero-elastic model were conducted. The research results have shown that the aerodynamic stability of the bridge during the construction stage or in-service stage is sufficient. The performance of VIV and buffet response under the design wind speed satisfies the demand of the code of wind-resistant design of highway bridges. The VIV amplitudes of the main deck from the section model with geometry scale of 1 to 25 are less than that of the main deck from the section model with a geometry scale of 1 to 60, which indicates that it is conservative to assess the VIV performance of the bridge deck with a section model of conventional scale section.