An endophytic actinomycete strain OsiSh-10 significantly against rice blast pathogens was successfully isolated from Xiangaizao 7 rice (Oryza indica) of Liuyang Dawei Mountain in Hunan Province. The control effects of OsiSh-10 on leaf blast in field were investigated by coating seeds and spraying leaf of rice with it, which were as follows: leaf blast was controlled by spraying OsiSh-10 on leaf of rice , but coated seeds with OsiSh-10 unworked for leaf blast. According to its morphological features, culture characteristics, physiological and biochemical characteristics, 16s rRNA gene sequence comparison, and phylogenetic tree construction analysis, OsiSh-10 strain was classified as Streptomyces albus. OsiSh-10 strain is a promising biocontrol actinomycete for rice blast.