For the particularity of design method of prestressed concrete frame beam, this paper took a prestressed concrete frame structure in the 8-degree (0.2g) seismic grade district as an example to study the rationality of moment amplification factors at column ends in the current code, and a design method that the prestressed concrete frame columns could be designed on the basis of the actual seismic flexural moment of the beam was also proposed. Eight prestressed concrete frames were designed according to the combined moment and actual seismic flexural moment. The static elasto-plastic analysis and dynamic elastic-plastic analysis were then carried out for the frame structures in OpenSees using fiber elements. Research shows that the prestressed concrete frame designed by using the current code has serious hinges at the first floor columns under rare earthquake. The seismic performance of yield failure mechanism of the structures was effectively improved with the increment of the factor. Moreover, as the value of moment amplification factors at column ends is low in 04 specification, it should be improved in the new specification. This paper recommends that for the prestressed concrete frame with second level seismic requirement, the moment amplification factors at column ends should be increased in the revision of code for seismic design of prestressed concrete structures, and on the basis of the combined moment at beam ends, the factor should be higher than 2.0, while on the basis of the actual seismic flexural moment, the factor should be 1.4.