The main building of three-tower ultra high-rise connecting buildings is significantly interfered by the podiums and annexes. Large eddy simulation was adopted for three-tower ultra-high-rise connecting buildings. The shape coefficients of the main building were calculated, and the computational results were compared with the wind tunnel test results. The wind fields, wind pressure coefficients, and the interference effects between tall buildings were discussed. It is found that the large eddy simulation was a feasible way, and the turbulent wind velocity was higher in condition with single building. The field of flow separation is more lasting in condition with three buildings. The interference effect might have beneficial sheltering effect on the wind-induced vibration response of the main building when the main building was in the upstream. On the contrary, the wind pressure of main building might have been magnified when the main building was in the downstream.