In view of the source of heavy metal pollution produced by the lead zinc tailings,a static leaching simulation test was carried out to study the different environmental influence factors on dissolution of zinc and arsenic in acidified sulfide mine tailings,taking the lead zinc tailings in Qinghai Province and acidithiobacillus ferrooxidans as the research objects. The main reasons and rules of the heavy metals release were analyzed during different periods so as to provide theoretical basis for the heavy metal pollution prevention and control of lead zinc tailings. The research results show that the relationship between Zn cumulative release amount of unit mass and the initial pH value of the solution expressed as pH2.0 > pH3.5 > pH4.5 was a negative correlation. The more the concentration of tailings was,the less the oxygen in contact with minerals was,and the less release of Zn and As. Compared with the leaching system without sodium sulfite,the release rules of heavy metals were obviously different,the added sodium sulfite increased the pH value of liquid and inhibited the release of Zn and As. Meanwhile,it is found that the release of Zn and As can be characterized into two stages. The early stage was given priority to acid solution and oxidation reduction. Adsorption and deposition reduced the release amount at the second stage. The new generated CaSO4 and Brushite covering mineral surface in the last stage also inhibited the continuous release of heavy metals. Release amount of Zn was greater than that of As,and the dissolution order is started from Zn to As,which can be attributed to the galvanic effect and more sensitiveness of Zn to the acid solution.