When structural seismic analysis is conducted on high-rise buildings, the impact of the infill wall stiffness on the structure response is usually considered by the fundamental period reduction factor in the PKRM software. In this paper, eight high-rise buildings in the Laibin High-Rise Testing Project were examined. These buildings were tested for ambient vibration and seismic analysis, which were also modeled and calibrated by the Finite Element (FE) Sap2000 software. First, eight FE models for the eight buildings were built in Sap2000. The same modeling for infilled wall using PKPM was also calculated, and the comparison of these two calculation results demonstrates the comparability of these two models. Next, shell model and diagonal strut model were adopted in the modeling of infill wall, and the models were calibrated by using the data from test. Thereafter, Sap2000 model was used for seismic response analysis instead of PKPM model. Finally, the seismic response spectrum analysis in linear elastic status was conducted under small earthquake. The comparison of the calculation results from PKPM software shows that, compared with the calculated value of calibrated model, the unreduced floor shear force calculated by PKPM is half of that by Sap2000, and the inter story displacement and inter story drift calculated by PKPM is three to four times of that by Sap2000. Moreover, the value of fundamental period reduction factor suggested by Technical Specification for Concrete Structures of Tall Building (JGJ3-2010) is 0.7~1.0, which is more conservative to the results obtained from the analysis.