Reinforced concrete（RC） frame beams will undergo large deformation stages in the process of collapse. In order to study the influence of bond-slip effect of reinforcing bars on the progressive collapse resistance of RC frame beams, especially in the suspension stage, the beam-column joint element was used to numerically validate the experimental results of a restrained beam substructure on the basis of OpenSees nonlinear finite element analysis platform and a set of parameters in the bond-slip model of reinforcing bars. The analysis results effectively reflect the elastic and plastic deformation, arch-compression effect and mechanical characteristics of the suspension stage of the structure, which are in good agreement with the experimental results. On the basis of the above analysis results, further simulations were conducted in a single-story plane RC frame structure and a three-story plane RC frame structure. In addition, the effects of number of stories and spans on the collapse-resistant performance of the plane frame structure were investigated. The force mechanism was also analyzed.