Three kinds of 2219 aluminum alloy with different iron Fe mass fractions were produced by ultrasonic semi-continuous casting method. The influence of Fe mass fraction on microstructure and properties of 2219 aluminum alloy was investigated by OM, SEM, tensile tests and electrochemical corrosion experiment. The results showed that the mechanical properties and corrosion resistance decreased obviously with the increase of Fe mass fraction, which was attributed to the generation of massive primary Al7Cu2（FeMn） phase and the increase of volume fraction of residual crystalline phases. The tensile fracture behavior of 2219 aluminum alloy at room temperature was mainly influenced by the brittle fracture of Al7Cu2（FeMn） phase, the crack direction of Al2Cu phase formed in the forging process and the low bonding strength at coarse residual crystalline phase/ Al matrix interfaces.