LIU Xiao-jie1,ZHAO Zhi-hu2, ZHAO Xiao-ying1, ZHANG Wen-dou2, LIU Xuan-ming1
(1. School of Biology, Hunan Univ, Changsha, Hunan410082, China; 2. Institute of Biological Engineering, Academy of Military Medical Science, Beijing100072, China） 在知网中查找 在百度中查找 在本站中查找
The datas of Neural Progenitor Cells chip and Embryonic Stem Cells ChIP-Seq from NCBI were analyzed to explore the function of RFX1. A comprehensive analysis showed that RFX1 binding sites spread across each chromosome. Most of them resided in chromosomes 1, 2, 4, 5, 7, 9 and 11, but the least in chromosome Y. And genome wide localization prediction showed that RFX1 binding sites ubiquitously and generally existed throughout the genome. 53.2% of these sequences were distributed in promoter, 22.5 % in the intergentic, 13.1% in the body, and 11.2% in the enhancer in the mouse genome. In addition, the biological processes of RFX1 target genes were analyzed. The majority of the affected biological processes were mainly cellular and metabolic.
