One type of noise barrier was chose as subjects, and the realistic simulation circumstance was constructed based on the distribution features of noise sensitive points near the proposed highway. Then, the prediction model of noise-reduction effects of noise barrier was built by Cadna/A software, and by utilizing this model, the parameters of this type of noise barrier were optimized. The research results revealed that this type of noise barrier can not only decrease the noise value of sensitive points to reach the environmental standards, but also minimize the construction cost when the right side noise barrier is 440 meters in length and 3.6 meters in height, and the left side is 400 meters in length and 4.4 meters in height.