For a new type of string reticulated mega-structure based on the concept of beam string structure and cylindrical reticulated mega-structure, five types of cable-strut arrangements were presented, and the influence of rise-span ratio on structural deformation in different cable-strut arrangement styles was also investigated. The maximum deflection, peak value of member internal force, horizontal support reaction, distribution of deflection and member internal force, ultimate load and buckling mode of the structure were analyzed and then compared with those of the corresponding structure without cables. The results indicate that the adoption of the prestressing system can significantly improve the structural deformation, peak value of member internal force and ultimate load. The static performance and stability of the structure can be improved most effectively when the struts and cables are arranged crosswise and symmetrically along the central wide range of span of the trussed arches, which is hereby the optimal arrangement scheme.