WANG Qiu-an1,WANG Sheng-chun1, LI Yue1, SHAN Yang2
(1.College of Chemistry and Chemical Engineering, Hunan Univ, Changsha, Hunan 410082, China;2. Institue of Agricultural Product Processing, Hunan Academy of Agricultural Science, Changsha, Hunan 410125, China) 在知网中查找 在百度中查找 在本站中查找
Two most abundant sources with the highest anticancer activity of natural polymethoxyflavonoids were oxidated by dimethyldioxirane ( DMDO ) to polymethoxy flavonoids 9 and 10 respectively. 9 or 10 were condensed with α-acetylglucosyl bromide, α-acetylgalactosyl bromide or α-acetylrhamnosyl bromide in dilute NaOH (aq)/CHCl3 system through phase transfer catalytic glycosation reaction, and followed by deacetylation, four new polymethoxyflavonoids glycosides 1~4 were synthesized. The structures of all the synthesized compounds were characterized by 1HNMR, 13CNMR and MS spectra. This synthetic method has the advantages of easy availability of starting materials，simple operation．
