A series of transparent UV-curable nonionic polyurethane (PU) hydrogel were prepared by the prepolymerization of polyethylene glycol 2000(PEG-2000), isophorone diisocyanate (IPDI), 2-hydroxyethyl acrylate (HEA), 1,4-butanediol (BDO) and glycerol (GLY). The influence of the proportion of BDO to GLY on swelling properties and tensile properties of PU hydrogel was studied. The effects of temperature and ionic strength on the swelling ratio (SR) of PU hydrogel were also investigated. The results indicated that when nBDO/nGLY=1, the tensile strength of PU hydrogel dry film reached 1.46 MPa, elongation was 87%, and SR was 370% in the deionized water at 20 ℃. Meanwhile, PU hydrogel showed strong temperature sensitivity and good stability to ionic strength. The release of the gentamycin sulfate from the swelling hydrogel in PBS buffer solution was eventually investigated to verify whether the obtained hydrogel can be used in drug delivery.