The aerodynamic performances of large wind turbine systems are significantly affected by blade yaw and interference, and then the wind-induced response and stability of the wind turbine system are changed. Taking the 5 MW wind turbine as the example，the flow field and aerodynamic forces of the wind turbine systems considering the six yaw angles (0, 5, 10, 20, 30 and 45 degrees) were simulated by large eddy simulation method, and the numerical simulation results were compared with standard curves to verify the validity of the numerical method. On this basis, the dynamic characteristics, wind-induced response and stability of the wind turbine systems under different yaw angles were analyzed by the finite element method. Main conclusions are as follows: The maximum values of the mean value and the mean square deviation of the radial displacement forthe tower under different yaw angles appearat 0 and 180 degrees, the maximum bending moment at the bottom of the tower appears in the circumferential direction of 20 degrees, and the peak value of three blade tip displacement response under 0 degrees yaw is more than 2.7 m. With the increase of the yaw angle, the mean value and mean square deviation of the radial displacement at the top of the tower, the forward displacement of the blade and the internal force of the blade root are gradually reduced, and the critical wind speed decreases first, then increases and decreases again. The results show that the aerodynamic performance and the wind-induced response of large wind turbine systems is the most unfavorable andthe largest under the 0 degree yaw angle, and the stability performance under 45 degrees yaw angle is the most unfavorable.