To study the progressive collapse performance of fully assembled concrete frame structures, based on the static and dynamic tests of two fully assembled specimens (PC1 and PC2) and one cast-in-situ specimen (RC), three sub-structural macro-models were established by using OpenSees finite element software, and the results of model verification were compared with test results. Two seven-story fully assembled frame structures (PC1-Frame, PC2-Frame) and a cast-in-situ frame (RC-Frame) were designed. Progressive collapse analysis was conducted for the residual structure of which middle and exterior column at the bottom were removed by using column removal method, respectively. The results showed that removing exterior columns was more easier to cause collapse than removing middle columns, and the displacement time history curve amplitude of failure point of PC1-Frame was larger than that of RC-Frame; The ultimate bearing capacity of PC1-Frame and PC2-Frame was 30% and 20.5% lower than that of RC-Frame in the case of removing mid-column, 26.9% and 22.3% lower in the case of removing exterior -column, respectively. Finally, the validity of the simplified non-linear dynamic analysis method based on the principle of equal energy was verified, and it is found that the dynamic amplification factor decreased with the structure entering the plastic stage.