Engineering application problem analysis often involves multi-body dynamics and fluid-solid coupling joint simulation，and the problem of pedestrian wading in wet road is a typical one. Multi-system co-simulation modeling and integral shoe “wading-outlet” process simulation analysis have a good reference value for the analysis of similar complex coupling problems in engineering applications. In this paper，a multi-body dynamic model of human lower limbs based on Adams/View was established to simulate pedestrian gait and then used as the boundary condition of shoe motion. A fluid-solid coupling model of shoe wading process was established，and the detailed “wading-outlet” process of the shoe was visually analyzed using the coupled Euler-Lagrange（CEL） method. It was found that the whole process can be divided into five stages：drainage，water pushing，water film formation，water film rupture and complete water discharge. Finally，wading simulation of sport shoes and flat shoes was performed，the volume fraction cloud map，water velocity map and system kinetic energy changes at various stages were compared，and the wading time and energy consumption were used as the evaluation index of wading performance，it can be found that the wading performance of flat shoes is weaker than that of sports shoes.