Through the finite element software of ABAQUS， the axial compression capacity of cold-formed thin-walled steel columns with web stiffeners and staggered holes was investigated. It was found that the results of the failure modes， load-displacement curves， and ultimate bearing capacities obtained from the experiments and the finite element analysis agree well with each other， validating the accuracy of the finite element model. Based on the validated finite element model， the effects of five parameters， including hole spacing， hole shape， slenderness ratio of the column， the height of web-stiffener， and flange width-thickness ratio， on the mechanical behavior of cold-formed thin-walled steel columns with web-stiffeners and staggered holes were analyzed. The results indicate that distortional buckling is the principal failure mode for all columns. The ultimate bearing capacity of the proposed columns with staggered holes increase with the increase in hole spacing， and the increment can reach more than 10% compared to the columns with side-by-side holes. Besides， the ultimate bearing capacity of the columns tends to ascend with the increase in the height of the web stiffeners， while it is barely affected by the hole shape. Compared with the V-shaped stiffened sections， the ultimate bearing capacity of the Σ-shaped stiffened section is increased by approximately 6.5%. In addition， the ultimate bearing capacity of the columns decreases with the increase of the column slenderness ratio and the flange width-thickness ratio.