Ventilated mattresses are designed to remove polluted air from the bedroom microenvironment by using a ventilation port located near the feet， thereby achieving pollution control at the source. However， experimental research has found a risk of local discomfort due to cold drafts caused by its use. Therefore， this study explores the automatic control potential of the ventilated mattress coupled with a local heating device based on local skin temperature， which can meet different thermal microenvironment needs of users by adjusting the mattress and local heating device in real-time according to users’ feedback. A comparison was made between the skin temperature and thermal acceptability of ten body parts of 30 awake subjects lying on the ventilated mattress， including the forehead， right scapula， upper left chest， upper right arm， lower left arm， left hand， front right thigh， lower left leg， right instep， and left instep. The acceptability of the whole body， face， forehead， neck， chest， back， arm， hand， thigh， leg， and foot were also recorded. The results showed that local female skin temperature was generally lower than male， while their acceptability was higher. The Gaussian regression model can calculate optimal skin temperature range for each part. Combined with the thermal acceptability correlation matrix results of each part and the control potential of the ventilated mattress and local heating device， the skin temperatures of the foot， hand， and back were finally selected to realize personalized automatic control of the bedroom microenvironment. This study provides new ideas and suggestions for exploring the automatic control potential of the ventilated mattress based on local skin temperature and could provide a reference for the optimization and improvement of the bed microenvironment.