To realize the rapid online diagnosis and alarm of the faults of power distribution equipment and water pumps in the pumping house of the water plant and its secondary booster pumping house so as to guarantee the safe operation of the pumping house system， an online diagnosis method of equipment in the pumping house is proposed based on the multipoint voltage and current information fusion. Based on the distribution equipment and pumps in the pumping house， the voltage and current characteristics of common faults in the power distribution equipment and water pumps in the pumping house， as well as the mutual influence mechanism of these faults， are systematically analyzed for the first time. The real-time voltage and current values of multiple key nodes in the distribution line are fused to extract the fault characteristics of six types of faults， including voltage overruns in the main circuit of the pumping house distribution， open air switches or contactors in the distribution line， open pump motor windings， imbalanced pump motor winding， inter-turn short circuit， pump blocking， connection break between the motor and pump， so as to realize the online diagnoses of these six types of faults. The implementation conditions of the method， the principle of implementation， and the specific steps are elaborated. Finally， MATLAB/Simulink is used to build a simulation model， which is experimentally verified. The simulation results show that the method can effectively diagnose the pumping house equipment faults， overcome the shortcomings of time-consuming and untimely offline analysis in the labor-intensive manual diagnosis， and provide effective protection for the safe operation of the distribution equipment and pumps in the water plant and its secondary booster pumping house.