To investigate the influence of process parameters on the online aerosol spray quenching of 7003 aluminum alloy profiles， a simulation model for online aerosol spray quenching of 7003 extruded aluminum alloy profiles was established in this study. The variations of the temperature and stress fields during the aerosol spray quenching process of 7003 aluminum alloy profiles were studied， and the reliability of the aerosol spray quenching simulation model for the profiles was verified by quenching experiments. The response surface optimization method was used to investigate the influence of profile running speed， longitudinal nozzle spacing， and air water ratio of circumferential air mist cooling nozzle on the online quenching time and maximum equivalent stress during the quenching process of the profile. The optimal production process parameters for online aerosol spray quenching of the profile are obtained. The research results show that the optimal process parameters are a profile running speed of 30 mm/s， a longitudinal nozzle spacing of 155 mm， and an air water ratio of 1.32. Compared with the pre-optimized parameters， the online aerosol sprap quenching time of the profile is reduced by 33.1%， the maximum equivalent stress during the quenching process is reduced by 21.2%， and the maximum residual stress is reduced by 62.9%. The efficiency and quenching quality of the profile online aerosol quenching are significantly improved.