In order to predict the buoyancy-driven flow and temperature fields influenced by coupling factors in residential buildings with atrium, the Multizone and Zonal methods were adopted to partition the building into zones. The prediction model of the loops between apartments and the atrium was established by means of mass, momentum, energy conservation equations. Furthermore, a reduce-scale model of 1/25, calculated by the similarity criteria of Archimedes number, was conducted to validate the accuracy of the prediction model. The calculated result of the prediction model agreed with the experiment data, which shows that the thermal environment in residential buildings with atrium can accurately be predicted with this prediction model.