Aiming at the problems of the serious turn heavy, front-wheel shimmying and front-wheel abrasion，this paper first framed the mathematical model of the steering knuckle.And according to the given target parameters, the key point coordinates of the steering knuckle in static equilibrium state were optimized and adjusted by the optimization tool of the MATLAB software. And then, based on the result of the calculation, we created a virtual prototype model of MacPherson Front Suspension in the ADAMS software. In the end, using Genetic Algorithm combined with ADAMS, the sum of the change of four alignment parameter values relative to the given value when the front wheel was jumping up and down was optimized. Optimization results have shown that the four alignment parameter values change with the objective values. The inclined angle, the tilt angle and the toe angle are reduced within the range of 32%, 24% and 34%,respectively. The camber angle has been in the externally-braced state, the movement characteristics of the front suspension are optimized and the co-simulation is convenient and feasible.