A finite element analysis was conducted on steel reinforced concrete frame supported by frameconcrete core structure with steel reinforced girder transfer story, and the general rules of the earthquake response were studied, when the height of transfer story and the ratio of equivalent lateral stiffness change. The results have shown that the height of transfer story can be set a little higher properly and suitable at a high altitude, and the outer frame should be reinforced around the transfer story for seismic design. When the transfer story is at a high altitude, the outer frame, up but next to the transfer story, should be specially strengthened, and when designing the outer frame of one or two upper stories, the corner columns should be more reinforced than other columns. Besides, the ratio of equivalent lateral stiffness should be ranged between 0.86 and 1.