The influence on the variation characteristics of aquifer parameters, induced by groundwater source heat pump (GWSHP) operation under constant flow and constant pressure difference, was theoretically analyzed by case study. The present study, compared with the constant flow operation, indicates that the porosity and hydraulic conductivity increase by 0.45% and 2.07% respectively under constant pressure difference operation. The influence on the variation characteristics of aquifer parameters, under constant pressure difference operation, is greater than constant flow operation. For the full penetrating well, the influence on the variation characteristics of aquifer parameters decreases gradually with the increase of the borehole diameter and aquifer thickness under different operation modes.