Ten quinolone-bonded porphyrins were designed and synthesized on the basis of both porphyrin’s photosensitivity and special affinity for tumor cells and quinolones’ antitumor and anticancer activities. The molecular structures of all synthesized compounds were characterized with 1H NMR, IR, UV-Vis and MS. The interaction between quinolone-bonded porphyrins and bovine serum albumin (BSA) was investigated with fluorescence spectrum. The results have shown that these new quinolone-bonded porphyrins have a powerful ability of quenching the fluorescence of BSA via static quenching.