In order to investigate the mechanical behavior of the hybrid system for the glass roof structure of new Guangzhou Railway Station, the prestress design of the lower cable-strut system was discussed. Then, the effect of the flexible members on the static behavior was studied. The linear eigenvalue buckling analysis and nonlinear buckling analysis on this system were carried out. At last, the influence of the area of upper steel beams, the area and prestress value of the upper track bars and lower cables on the vertical stiffness was investigated. The results have shown that the upper track bar and lower cable increase the structural stiffness. The whole stability of the hybrid system of this project can meet the demand, but the end of the structure is the weakest area. The structural vertical stiffness increases with the increase of the area of the upper beams. Moreover, the increasing area and prestress value of the upper track bar slightly increase the vertical stiffness. The influence of the area of the lower cables on the structural stiffness is significant, but the stiffness is not appreciably affected by the prestress of lower cables.