The influence of the structure parameters of the lifting composite hydro-pneumatic suspension on vehicle performance was analyzed by taking the suspension frequencies under basic load, maximum load and the difference between them as the evaluation indexes. A matching and optimization of the structure parameters of the composite hydro-pneumatic suspension of a vehicle was then investigated. The optimization was carried out by taking the suspension boundaries and loading status as the constraints, the product of the quadratic sum of the suspension frequencies at basic load and maximum load and the difference between the two frequencies as the objective functions, and the structure parameters of the lifting composite hydro-pneumatic suspension as design variables. Finally, an appropriate set of structure parameters of the lifting composite hydro-pneumatic suspension was obtained, which will meet both the design constraints and the requirements of ride performance.