In this study, we have synthesized a series of new norlignan compounds ——2a~2g—— and evaluated their anticancer activities with MTT assay by using human hepaioma Bel-7402 cells, human breast adenocarcinoma MCF-7 cells, human lung carcinoma A549 cells and human cervical carcinoma HeLa cells. It has been shown that the products (——2a~2g——) exhibit higher cytotoxicity to cells, and especially, product ——2b—— treated with Bel-7402 cells shows a lower cytotoxicity (IC50: 18.9 μg/mL) than free paclitaxel.