To solve the problems of low prestressed efficiency in concrete slab and local buckling of steel web in hogging moment region of prestressed steel-concrete continuous composite beams (PCB), a hybrid design method with the corrugated steel webs in hogging moment region instead of plane steel webs was proposed. The force and deformation behaviors of prestressed steel-concrete continuous composite beams with partial corrugated steel webs (PCBW) were studied by theoretical calculation and finite element analysis and were compared with PCB. The research results demonstrate that the hybrid design method can take full advantage of the low axial stiffness and excellent anti-buckling ability of corrugated steel webs, improve the prestressed efficiency and the cracking load in concrete slab. PCBW is particularly suitable for long and medium-span prestressed continuous composite beam structures.