To optimize the equivalent static wind loads（ESWL）of tall buildings, a global optimization method that combined wind tunnel test results with finite-element analysis was proposed. Dynamic characteristics of structure were computed by finite element analysis, combined with wind tunnel test results of scale model. ESWLs for prototype were calculated through gust load factor (GLF).Then optimization toolbox of ANSYS was used to optimize ESWL, taking the minimum weight as the target function and the limit top displacement of the tall building as the constraint. Finally, the global optimization method was applied to optimize the ESWL of a 60-storey steel frame structure. The results have shown that the equivalent static wind load can be reduced by 10.71% after optimization, when the optimal design is conducted subjected to the condition to meet the requirement of the top displacement of the tall building. In addition, the feasibility of the global optimization method has also been validated.