Slopes with red beds are often reinforced by anchors. But the disintegration characteristics of the red sandstone have direct influence on the mechanical properties of the anchors. Thus, it is required to study the laws between the disintegrating resistance characteristics of the red sandstone and the mechanical properties of the anchors. In this paper, anchor pullout tests in red sandstone layers and disintegrating resistance tests of red sandstone were carried out. Firstly, the evolution rules of the load-displacement curves and the loading elastic-plastic displacement curves of the anchors in red beds under cycling loads were obtained through anchor pullout tests. Secondly, the disintegrating resistance index was acquired under the disintegrating resistance tests. At last, the laws between the disintegrating resistance characteristics of the red sandstone and the mechanical properties of the anchors were combined. The analysis shows that, with the reduction of disintegrating resistance index, the mechanical properties of the resistance of pullout become poor.