The synthesis of zinc porphyrins tailed by 4,4'-biphenyldiol and their spectral property studies were reported. The results showed that the maximum fluorescence emission wavelength of these zinc porphyrins tailed by 4,4'-biphenyldiol was about 650 nm, which was located in the visible light region, and was satisfied with the optical properties of the ideal photodynamictherapy drugs. The zinc porphyrins tailed by 4,4'-biphenyldiol will become an excellent photosensitizer.