In order to deal with the decision-making ambiguity in practical production scheduling, this paper put forward a decision-making method based on the combination of priority rule and fuzzy synthetic evaluation. Through analysis of the task assignment process in practical production scheduling, the influencing factors relevant to task priority and machine priority were found. By using membership function to express the priority degree influencing factors, the problems of representing uncertainty and preference information in practical shop scheduling were solved. With fuzzy synthetic evaluation calculation aiming at computing the priority degree of tasks and machines, many problems in synthetic tradeoff were solved successfully. Eventually, examples were utilized to explain the calculation process of this method, and practical shop scheduling was applied to analyze the feasibility of this method.