In order to obtain the interface friction characteristics between reinforcement and coal gangue mixed with different qualities of soli, large-shear tests were carried out. The test used gabion mesh galvanized and covered with plastics. The filler was coal gangue mixed with different qualities of soil and prepared with the optimum moisture content. The samples controlled the compaction of 94%. The results showed that the relationship between shear stress and displacement on the interface friction and coal gangue and reinforcement was nonlinear, and the shear stress on the interface friction increased with the increase of normal stress.The parameters of the interface friction strength changed regularly with the increase in the amount of soil when the mixed soil was less than 20%. When the mixed soil increased, the interface cohesion decreased first and then increased, but the interface friction angle first increased and then decreased. The strength parameters of the coal gangue mixed with reinforcement conformed to the theoretical formual Mohr. The formula not only reflects the cohension between coal gangue and reinforcement, but also has a better correlation coefficient.