Based on the wind tunnel testing of a low-rise building, the wind pressure characteristics of the low-rise building with holes of different sizes and shapes on its roof corner were analyzed. The superimposition of internal and external pressures makes the emergence of large positive pressure on the roof. The internal pressure shows an overall uniform distribution. With the opening area becoming smaller, the internal pressure gets stronger. The probability density function of the internal pressure is closer to the Gaussian distribution, and when compared with external pressure, the non-Gaussian characteristic of net pressure is weakened. The internal pressure also exhibits a strong correlation in frequency domain. There appear two humps in the internal pressure spectrum corresponding to Helmholtz frequency and vortex shedding frequency, and the peak of the vortex shedding frequency is offset for the case of net pressure. Furthermore, the internal pressure characteristics indirectly show that the length of the front edge enhances the development of the conical vortices and the conical vortices appearing in pairs do not become the strongest simultaneously.