According to the current code for seismic design of prestressed concrete structures (JGJ140-2004), this paper discussed the problem of reasonable value about moment magnifying coefficients at column ends of multi-layer prestressed concrete frame structure in the 8 degrees (0.2 g) seismic grade district. Six elasto-plastic analysis models with different moment magnifying coefficients at column ends based on local fiber hinge beam element were established in SAP2000 and PERFORM-3D respectively, and the static elasto-plastic analysis (Pushover) and dynamic elastic-plastic analysis were proceeded. The analysis results show that PC frame designed by the current aseismic codes forms the beam-column hinge hybrid yield mechanism, in which column hinge occupies the priority, adverse to the earthquake. As the moment magnifying coefficients at column ends increased gradually, the seismic performance of local components and yield failure mechanism of structure showed significant improvement. If the moment magnifying coefficients of middle and side columns separately increased at 2.0 and 1.8, PC frame can form beam-column hinge hybrid yield mechanism, in which beam hinge or even beam hinge yield mechanism occupied the priority, favorable to the earthquake. Therefore, suggestions were given to improve appropriately the moment magnifying coefficients at the frame column end in the revision of code for seismic design of prestressed concrete structures.