This paper studied the technology of removing calcium and magnesium ions from manganese sulfate leaching solution prepared in two-ores method with poor pyrolusite. The results are as follows: using 30% P204 added 70% sulfonated kerosene as the extraction solvent, saponification rate 60%, temperature 25 ℃, phase ration(O/A)3∶1, and keeping pH of solution about 6.0 at the beginning, the extraction yields of the calcium and magnesium ions are 99.37% and 90.62% respectively. Calcium and magnesium ions content can be reduced to less than 100 ppm, and high purity manganese sulfate solution from which calcium and magnesium ions have been removed deeply can be obtained. In the loaded organic phase via 4.0 mol/L sulfuric acid stripping, metal ions were stripped completely. The economically feasible process of using the leaching purification liquid and stripping liquid to preparation of high purity manganese compounds was designed, and the whole process of integrated application of manganese sulfate leaching solution was achieved.