The average wind pressure on the internal surface of a super large hyperbolic cooling tower under the operating conditions was simulated in CFD method. Based on computational fluid dynamics software for secondary development, DPM model combined with a UDF function method was used to study the average wind pressure on the internal surface of a super large cooling tower. The Lagrangian method was used to simulate the water phase of the tower and Euler method was adopted to simulate the air phase, the coupling calculation between inner flow field and transformation of heat and mass in cooling tower under the operating conditions was well realized, and the internal pressure distribution law of cooling tower under crosswind direction with running state was analyzed. The results of the tower with no cross wind show that the symmetry of the average pressure on the internal surface goes well, and the water temperature is consistent with the test result, which verifies the effectiveness of the method proposed. The value of the average pressure coefficient of the internal surface of cooling tower under cross wind becomes bigger along the height direction, and the value does not change significantly along the latitudinal direction. The shortcomings of the current code about internal surface pressure coefficient were discussed, and the recommended values were given, which provides methods and basis for the calculation of the internal pressure of super large cooling tower design.