Injury of the lower limb is one of the most common injuries in vehicle-to-pedestrian crashes. Therefore, accurate Finite Element (FE) models of pedestrian lower limb with high biofidelity play an important role in developing effective research techniques for the protection of the lower limb. The models of lower limb long bones (femur, tibia, and fibula), knee ligaments (ACL, PCL, MCL, LCL) and knee joint were fully validated in previous studies. On that basis, FE model of pedestrian lower limb, including skeletons, ligaments, muscles and skins, was developed, and contact properties among different tissues were defined. Based on the biomechanical experiments conducted by Kajzer et al., the FE model was validated against the whole pedestrian lower limb bending tests. The results have indicated that the injury types, injury occurring moments, knee joint bending moments and bending angles of the lower limb FE model are consistent with the experiment data. This model is capable of accurately reflecting the pedestrian lower limb injuries and biomechanical responses in impact processes with higher biofidelity.