The effect of indoor thermal environmental parameters on human body exergy consumption was analyzed from the thermodynamic point of view. The definitions of human body exergy and human body exergy consumption were given, and also the calculation base point of human body exergy. Typical office building environment in winter was selected as research object, and the effect of indoor thermal environmental parameters on human body exergy consumption was quantitatively analyzed. The results show that the change of indoor air temperature or mean radiant temperature has relatively small effect on the human body exergy consumption when indoor air relative humidity ranges from 10% to 50%, and the change of indoor air relative humidity has relatively large effect on the human body exergy consumption when both indoor air temperature and mean radiant temperature are less than 20 ℃.