In order to study the influence of exterior cladding walls on the seismic performance of frame structure，especially the impact on siding horizontal stiffness of structures, strength and deformation capacity, three full-scale reinforced concrete frame structures including pure cast, siding with the beam and siding with both the beam and the column were tested under cyclic loading to a maximum inter storey drifter angle of 1/16 rad. The experiment results indicate that three specimens exhibit steady hysteretic behavior and excellent ductility. After the connection with the column was disengaged, the impact on the strength of the structure can be ignored. The cladding walls have a significant impact on the initial stiffness of the structure, and the siding with the frame and beam increases the stiffness more obviously than the effect when the siding is only connected to the beam. The connections between the cladding panels and the beam have no noticeable damage, and the panel remains intact when the inter storey displace angle reaches 1/16, indicating that the connections between the structure and the exterior cladding walls can meet the design requirements of major earthquakes.